I-33: Early Assessment of Pregnancy Viability

Early determination of pregnancy viability is essential for women at risk for experiencing ectopic pregnancy or spontaneous abortion. Several markers of pregnancy viability have been identified including serial human chorionic gonadotropin (hCG) monitoring and sonography, in addition to several less commonly available biochemical markers. An ideal test would be readily available, inexpensive and able to determine probability of live birth following one visit. This study reviewed 1729 IVF cycles of patients that had embryo transfer (ET) either 3 or 5 days following oocyte retrieval (OR) and an hCG determination 15 days after OR. Multivariate analyses and receiver operating characteristic curves were performed to analyze the data with the intention of determining hCG thresholds for the prediction of live births and failed pregnancies for embryos transferred on both days 3 and 5. Thresholds were also detected for prediction of multiple pregnancy.